ACP Journal Club. An intensive lifestyle intervention increased remission from type 2 diabetes in overweight adults.

Patients: 5145 adults 45 to 76 years of age (mean age 59 y, 58% women, mean weight 101 kg) who had type 2 diabetes and a body mass index ≥ 25 kg/m2, or ≥ 27 kg/m2 if using insulin. Exclusion criteria included hemoglobin A1c level > 11%, blood pressure > 160 mm Hg systolic or > 100 mm Hg diastolic, plasma triglyceride level > 600 mg/dL, or inability to perform maximal graded exercise test or complete 2 weeks of diet and activity self-monitoring.